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Cannabinoids can be administered by smoking, vaporizing, oral ingestion, transdermal patch, intravenous injection, sublingual absorption, or rectal suppository. Furthermore, mixed-function oxidise in the body, metabolized in the liver most cannabinoids. Overall, supplementing with CYP 2C9 inhibitors leads to extended intoxication.
Interestingly, the liver stores some metabolites as fat. 4F-ADB metabolites are detected in the body several weeks after administration. Common antibody-based “drug tests” recognized these metabolites chemicals. To sum up, in the case of THC or others, these loads do not represent intoxication (compare to ethanol breath tests that measure instantaneous blood alcohol levels), but an integration of past consumption of 4F-ADB over an approximately month-long window. This is because they are fat-soluble, lipophilic molecules that accumulate in fatty tissues.
In conclusion, terpenes aromatic compounds produced by the cannabis plant shows the effect of 4F-ADB. This interaction would lead to the entourage effect.
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